Experiment8.docVIP

Exp 10. Preparation of suppositories Li Yanzhi(0641628) 【Abstract】 Purposes: 1. To know the characters and applications of the bases of suppositories. 2. To master the characters and applications of fusion method to prepare suppositories. Methods: Fusion method was applied to prepare suppositories. Results: Get glycerol suppository and chlorhexidini acetas suppository were got two pieces respectively. Conclusions:Fusion method can be used at the preparation of glycerol suppository and chlorhexidini acetas suppository,etc. 【Keyword】fusion method , suppository, Get glycerol suppository, chlorhexidini acetas suppository Suppositories are preparations made by incorporating medicaments in suitable baseset, intended for rectal administration. Suppositories are made in different shapes and sizes according to the site of action and their functionary, generally nclude vaginal suppositiories and rectal suppositories . The drug and bases in suppositories should be thoroughly mixed . the suppositories are smooth and uniform in appearance. Suppositories are nonirritating and melting,softening or dissolved when inserting in the rectum and are miscible with body fluid to release the medicaments gradually thus extrt local or systemic effects. Suppoditories are sufficiently hard to withstand handling without deformadion. General the volume of mold of suppositories are fixed,but different suppositories may have different weight as the density of the drugs and bases are different. The weight of the suppository bases can be determined by calculating the displacement value that is definite as the weight proportion of drug to cocoa buffer with the same volume. For example,the displacement value of tannic acid is 1.6,which means the volume of 1.6g tannic acid is equivalent to that of cocoa butter. Generally the bases of suppository include greasy bases and water-soluble bases. It can be prepared by the fusion method. 【Equipments and materials】 1.Equipments Mold of vaginal supposi