（新）400t红霉素生产工厂的初步设计.docVIP

400 t/a 红霉素生产工厂的初步设计 专业：生物工程 摘要Major: Biology Engineering Author: Fu Xiangke Supervisor: Li Huidong (School of Life Sciences Hunan University of Science and Technology 0709030226) Abstract：The Fermentation Engineering and Equipment Course Design can play the connecting role between the preceding and the following in the practice teaching, and lay a good foundation for the students to work in the factory after graduation. This subject is an initial technological design for Erythromycin with year output of 300 ton.According to the requirement,the process of erythromycin production and the calculation of the mass balance and heat quantity balance are completed. In this subject , all of theprocesses are expounded in detail. All the contents are based on the academic calculations .we refer to the practical designes in companies and make our best to approach to the practice. it mainly includes the production craft each kind of target,the equipment chooses the shapedesign calculation,material of the graduated arm of a steelyard calculation,the water,the electricity,the steam estimate as well as the flow chart design.This designachievement mainly uses the form for the entire factory totalfloor-plan(1),flowchat(1),equipment general arrangement(1),and compilation particular data instruction booklet.. Key word: Erythromycin; Process; Design  1 绪论 1.1 红霉素的理化性质 ）分子式 ： 分子量733.94 g/mol 结构：红霉素是由红霉内酯与去氧氨基己糖和红霉糖缩合而成的碱性苷。红霉内酯环含有13个碳原子，内酯环的C-3通过氧原子与红霉糖相联结，C-5通过氧原子与去氧氨基己糖相连接。红霉糖本身不含氮，是含有 一个甲氧基的己糖，去氧氨基己糖。 成分由链霉素Streptomycin elytrous所产生，是一种碱性抗生素。其游离碱供口服用，乳糖酸盐供注射用。此外，尚有其琥珀酸乙酯（琥乙红霉素）、丙酸酯的十二烷基硫酸盐（依托红霉素）供药用。别名威霉素; 福爱力；新红康 中文名称IUPAC）：(3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-((2,6-脱氧基-3-碳-甲基-3-氧-甲基-α-L-核-己吡喃糖基)-氧)-14-乙基-7,12,13-三羟基-3,5,7,9,11,13-六甲基-6-((3,4,6-三脱氧-3-(二甲氨基)-β-D-木-己吡喃糖基)-氧)氧杂环十四烷-2,10-二酮通用名红霉素λmax 红霉素A 红霉素B 红霉素C 红霉素D 红霉素E C37H67O13N C37H67O12N C36H65O13N C36H65O12N C37H65O14N 733.91 717.91 719.88 703.45 735.88 135—140 198 121—125 — 160—165 －7