肿瘤信号通路课件.pptVIP

* The traditional signal transduction mechanism for G protein coupled receptors is through trimeric G proteins. The prediction is that coupling of SRC tyrosine kinases through arrestin will also be a very general mechanism for signal transduction in this class of receptors. In addition to this there is a multitude of other transmembrane signaling mechanisms that tend to be more “receptor specific”. One example of a “receptor specific” mechanism is initiated from a poly proline (pPRO) site in the C–terminal region of mGluR receptors. pPro is the signal motif which binds to SH3 regio