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* * * * * * * * * * * * * * * * * * * * * * * * * ERNE Architecture Connecting Research Designing the EDRN informatics architecture as a collection of well-defined components via OODT has simplified the process of building interfaces to non-EDRN systems Wrappers can be built to link non-EDRN systems Translators can be developed to deal with different semantic architectures caBIG ERNE/caTissue Wrapper EDRN-Canary Collaboration A cloud computing effort that shares raw science data via Amazon S3 between EDRN and the Canary group which uses software from GenoLogics Life Sciences EDRN Knowledge Environment Building a Semantic Bioinformatics Grid for the EDRN Lessons From EDRN Architecture and a vision has been critical Technology hasn’t been as critical Keep it simple Science support has been critical Getting buy-in and participation from domain experts is key Incremental development and deployment Starting with a few sites was very helpful in understanding the issues We had both development sites and observer sites initially The IRB process has been a big schedule driver Distributed architecture can be a challenge Not all sites up to maintaining the implementation Loosely coupled architecture with simple interfaces helped Applications of OODT: VPICU Whittier Virtual Pediatric Intensive Care Unit Childrens Hospital Los Angeles Collaboration between 85 Multi-disciplinary pediatric intensive care units across the U.S. Collaboration with VPICU Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit (VPICU), founded in 1998 by clinicians at CHLA Leverage advances in technology to: Improve patient care Educate practitioners Conduct research Reduce cost of providing care VPICU Research Data Real Health Care Data Set Massive, grows continuously Heterogeneous formats, types, etc. Incomplete, proprietary, descriptions Fragmented across stores, organizational boundaries Incomplete, inconsistent Highly restricted (legal, privacy, ethical considerations
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