不對称的细胞分裂促进表皮分化缺口依赖.docVIP

不对称的细胞分裂促进表皮分化缺口依赖 Scott E. Williams, Slobodan Beronja, H. Amalia Pasolli, and Elaine Fuchs 1 ，H.阿玛利亚Pasolli，Beronja斯洛博丹·斯科特·E.·威廉姆斯，和伊莱恩福克斯1 Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology Development, The Rockefeller University, New York, New York 10065, USA.霍华德休斯医学研究所，实验室，哺乳动物细胞生物学与发展，洛克菲勒大学，纽约，纽约10065，USA。 Elaine Fuchs: fuchslb@ 伊莱恩的福克斯fuchslb@ 1 To whom correspondence should be addressed: Elaine Fuchs, Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY, 10065, USA. 1谁信件应该得到解决：伊莱恩福克斯，霍华德休斯医学研究所，实验室，哺乳动物细胞生物学与发展，洛克菲勒大学，1230纽约大街300箱，纽约，NY，10065，USA。 Phone: 212-327-7953, Fax: 212-327-7954,电话：212-327-7953，传真：212-327-7954， Email: fuchslb@ 电子邮件fuchslb@ fuchslb@ Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: /authors/editorial_policies/license.html#terms用户可以查看，打印，复制，下载和文字，进行数据挖掘等文件中的内容，学术研究的目的，主题总是完整的使用条件： /authors/editorial_policies / license.html中＃条款 The publishers final edited version of this article is available at Nature出版商的最终编辑版本的这篇文章是在自然 See other articles in PMC that cite the published article.参见其他文章PMC 引用发表的文章。 Other Sections▼ 第▼ Summary 总结 Introduction 介绍 Results 结果 Discussion 讨论 Methods Summary 方法总结 Methods 方法 Supplementary Material 补充材料 References 参考文献 Summary总结 Stem and progenitor cells utilize asymmetric cell divisions to balance proliferation and differentiation.干细胞和祖细胞利用非对称细胞分裂，到平衡的增殖和分化。 Evidence from lower eukaryotes shows that this process is regulated by proteins asymmetrically distributed at the cell cortex during mitosis: (1) Par3-Par6-aPKC, conferring polarity; (2) Gαi-LGN/AGS3-NuMA-p150 glued , governing spindle positioning.从低等真核生物的证据表明，这个过程是受非对称分布的蛋白质在细胞皮层，在有丝分裂过程中：（1）Par3的PAR6 aPKC，赋予极性（2）Gαi-LGN/AGS3-NuMA-p150 粘 ，执政主轴定位。 Here, we focus on developing mouse skin, where progeni