肺癌的生物)靶向治疗进展.pptVIP

肺癌的生物靶向治疗进展 Current Anti-Cancer Approaches Why do we need new anticancer agents? What makes an ideal therapeutic target? Present in the majority of patients with specific tumor type Causative link with tumourigenesis Essential function in tumor cells Assessing novel targeted agents EGFR Iressa, Tarceva, C225 血管生成 Avastin COX-2 Celecoxib EGFR expression in human tumours High expression is generally associated with invasion metastasis late-stage disease chemotherapy resistance hormonal therapy resistance poor outcome EGFR highly expressed in NSCLC Extensive clinic