子宫内膜癌EphB4ERα和ERβ的表达及意义.docVIP

子宫内膜癌EphB4和ERα,ERβ的表达及意义 赵玉斌1 吕杰1 张少华1 苏光森2 徐治伟2 张积仁3 1山东省即墨市人民医院（肿瘤科：赵玉斌；心内科：张少华；普外科：吕杰）；2山东省诸城市人民医院（肿瘤科：苏光森；放射科：徐治伟）262200；2 266200；；3南方医科大学珠江医院肿瘤中心主任、博士生研究导师510282 第一作者简介：赵玉斌（1972-），男，山东诸城人，博士，研究方向：肿瘤靶向治疗的基础与临床研究。电话 E-mail: zhaoyubin2005@126.com 第一作者即通讯作者 【摘要】目的 研究EphB4和ERα,ERβ等各自的蛋白在子宫内膜癌中的表达及其意义。方法 用免疫组织化学SP法检测71例子宫内膜癌组织中EphB4和ERα, ERβ等各自蛋白的表达水平。结果 1. EphB4和ERα, ERβ71例子宫内膜癌组织中别为69.3%, 52.3％和60.6 %2. 子宫内膜癌EphB4蛋白的阳性率与组织学分级淋巴结转移、临床分期和年龄显著相关 (P0.05)。3. ERα蛋白的阳性率与子宫内膜癌的淋巴结转移、病理类型、组织学分级和临床分期显著相关(P0.05)。 ERβ蛋白的阳性与淋巴结转移显著相关(P0.05)。4. EphB4 蛋白的阳性率与ERα, ERβ蛋白的阳性率均显著相关(P0.05)。结论 EphB4、ERα、ERβ可能与子宫内膜癌的发生发展有关。它们的联合检测宫内膜癌的物学行为客观评估 可用来指导临床和预测预后。 关键词：EphB4; ERα; ERβ; 免疫组织化学; 子宫内膜癌 xpression of EphB4 and ERα, ERβ in Endometrical Carcinoma and Their Significance Zhao Yubin, Zhang Shaohua, LǚJie (People’s Hospital of JImo, ShanDong Province,China); Su Guangsen, Xu Zhiwei(People’s Hospital of Zhucheng, ShanDong Province, China); Zhang Jiren(Oncology Department of Zhujiang Hospital, Southern Medical University,China) 【ABSTRACT】Objectives: To study the protein expression of EphB4, ERα and ERβ and their significance in endometrical carcinomas. Methods：he protein expression of EphB4, ERα and ERβ in 71 endometrical carcinomas were detected by immunohistochemistry Sp method. Results：1. Among the 71 endometrical carcinoma cases, the positive rate of EphB4, ERα and ERβ was 69.3%, 52.1% and 60.6% respectively. 2. The positive expression of EphB4 protein were with istological grade, lymph node metastasis, clinical stage and age (P0.05). 3. The protein expression of ERα was associated with lymph node metastasis, pathological type, histological grade and clinical stage (P＞0.05). The expression of ERβ protein was related with lymph node metastasis (P0.05). 4. Their were significant correlations between the protein expression of EphB4 and ERα, ERβ (P0.05). Conclusions：EphB4, ERα and ERβ may be involved in carcinogenesis, development procedures of endometrical carcinoma. The co