甲型H1N1流感C反应蛋白与白细胞的相关分析..docVIP

甲型H1N1流感C反应蛋白与白细胞的关系分析 周晓飞 罗冬霞 周凤先 王玥莲 温贤敏 曾义岚 刘大凤* 摘要：[目的]探讨甲型H1N1流感CRP与WBC的关系。[方法] 回顾性分析2009年实验室确诊的271例住院患者不同临床类型、疾病不同阶段CRP与WBC的关系。 [结果] 1）甲型H1N1流感患者感染初期CRP升高常见，且升高程度随着病情的加重而更明显；2）轻症患者CRP升高幅度＜3ULN，重症患者CRP升高幅度达10 ULN，危重症患者CRP升高幅度达20 ULN；3）Pearson相关分析显示，感染初期CRP与年龄、WBC及GR%均呈正相关；当校正了年龄后，偏相关分析发现CRP仍与WBC呈正相关，与GR%的相关性消失。[结论] 甲型H1N1流感患者CRP升高常见，轻度升高（＜3ULN）与病毒感染所致的炎症反映有关，明显升高（≥10ULN）提示合并细菌感染。 关键词： 甲型H1N1流感 C反应蛋白 白细胞 相关性 Relationship between C-reactive protein and white blood cell in patients with influenza A (H1N1) Zhou Xiao-fei, Luo Dong-xia, Zhou Feng-xian, Wang Yue-lian, Wen Xian-ming, Zeng Yi-lan, Liu Da-feng* (The Infectious Disease Hospital of Chengdu, Chengdu 610061, China) Abstract：[Objective] To analyze relationship between C-reactive protein (CRP) and white blood cell(WBC) in different clinical stage and different clinical sever degree in influenza A(H1NI) cases confirmed in Sichuan..[Methods] Retrospective analysis of hospital admitted 271 cases in 2009 Influenza A(H1N1) influenza cases relationship between CRP and WBC in different clinical stage and different clinical sever degree in influenza A(H1NI) cases confirmed in Sichuan.. [Results] 1) CRP was elevated in earlier time in influenza A(H1NI). The elevated degree was increased together with increased severity of disease.2). The elevated degree of CRP in mild cases was usually less than three times of upper line normal (ULN).But it was ten times and twenty times of ULN in cases with heavy clinical features and cases with serious critical clinical features respectively. 3) Pearson correlation analyses showed that CRP was positively correlated with age ,WBC and neutral granular cell percentage(GR%). Adjusting for age, partial correlation analyses showed that CRP was still positively correlated with WBC, but there was no relation between CRP and GR%. [Conclusions] CRP was usually elevated in earlier time in influenza A(H1NI). Mild elevation (less than three times of ULN) refers to viral infection resulting in