【2017年整理】分子生物学综述1.docxVIP

分子生物学综述 《肌萎缩侧索硬化症的基因分析和基因治疗进展》 姓名：胡莉琴 学号：416522811456 专业：神经病学 单位：南昌大学医学部 肌萎缩侧索硬化症的基因分析和基因治疗进展 ABSTRACT: OBJECTIVE: Explore amyotrophic lateral sclerosis in the virulence genes and gene therapy are reviewed. DATA SOURCES: An computer-based online search of Pubmed database was undertaken to indentify articles published in English between 1993 and 2011 by using the keywords of “amyotrophic lateral sclerosis,gene,gene therapy” Chinese relevant article published from 2005-2011 were searched with computer in WEI PU. STUDY SELECTION；The data were checked firstly, the articles on amyotrophic lateral sclerosis were collected. Inclusive criteria: ①Research amyotrophic lateral sclerosis of virulence genes; ②Amyotrophic lateral sclerosis gene therapy research. Exclusive criterial:①Drug therapy; ②repetitive studies and experiential and individual literature report. DATA EXTRACTION: Totally 116 articles in all on amyotrophic lateral sclerosis were collected ,of which 32 articles were selected. DATA SYNTHESIS: The pathogenesis of amyotrophic lateral sclerosis and SOD1 gene mutations may be relevant. When SOD1 genetic change, its code of protein conformation also produces change, enzyme activity reduced, scavenging free radicals ability. In amyotrophic lateral sclerosis gene therapy, neural factor can promote motor neuron in the survival and growth and repair, iRNA can delay the motor neuron degeneration of the development. CONCLUSION: For amyotrophic lateral sclerosis to explore its pathogenesis, for ALS gene therapy to lay the foundation, thus heal ALS. KEYWORDS: amyotrophic lateral sclerosis ;gene; gene therapy 摘要： 目的： 探讨肌萎缩侧索硬化症在致 基因和基因治疗方面的研究进展。 资料来源：应用计算机检索Pubmed1993-2011年的文章，检索词为“amyotrophic lateral sclerosis,gene,gene therapy”,限定语言种类为中英文，同时计算机检索维普数据库2005-2011年期间的相关文章。 资料选择：对资料进行初审，选取有关肌萎缩侧索硬化症方面的研究。纳入选标准：1.研究肌萎缩侧索硬化症的致病基因等方面的研究。2肌萎缩侧索硬化症的基因治疗的研究。排除标准：1.药物治疗的研究。2.重复研究及经验和个人报告文献。 资料提炼： 共检索到116篇关于肌萎缩侧索硬化症致病基因及基因治疗等研究的文献，入选32篇。 资料综合： 肌萎缩侧索硬化症的发病机制可能和SOD1基因突变有关。当SOD1基因发生