HIV__培训课件.ppt

The comparison of HIV genome human genome HIV: 9 Human:20000~25000 mutation rate= 100X HIV-clever virus High mutation rate Quacispecies ( 1000~10000/ml) Stimulate Ab via diverse region of gp120 Laboratory diagnosis of HIV infection Antibody detection tests (late infection): Ab to P24, RT, gp120 Antigen detection tests (acute infection): P24 antigen (viral protein) proviral DNA (by PCR) * Discovery of HIV it’s pathogenesis The Nobel Prize in Physiology / Medicine 2008 The History of HIV’s discovery 1981 In New york several young gay men developed Kaposis’sarcoma- a rare cancer usually affected old people In California five young gay men developed pneumocystis carinii pneumonia (PCP)-an unusual lung infection What was happenning? The History of HIV’s discovery A new disease…… Immune system related? Cytomegalovirus?-a virus found in more than half of the population Poppers?-drugs heavily used in the gay community The History of HIV’s discovery CD4-T↓ severe immunodeficiency dead in a short time GRID (Gay related immunodeficiency) 1982-- Luc Montagnier 1983-- Francoise.Barre-sinoussi RT was detected Lymphadenopathy associated Virus (LAV) The History of HIV’s discovery 1984-Apr--Robert C.Gallo, HTLV III (Human T-lymphocytic Virus) 1984-May--《Science》 The History of HIV’s discovery The History of HIV’s discovery 1986-- HIV (human immunodeficiency virus) was named by the International Committee on Taxonomy of Viruses (ICTV) The History of HIV’s discovery The new disease became known as AIDS Acquired-people acquire the disease, but they don’t inherit it Immune-it affects the immune system of the body Deficiency-the immune system stop working properly Syndrome-it involves a range of illness, not a single disease The His