题目-第三军医大学学报.docVIP

雷贝拉唑对功能性消化不良患者阻抗式胃动力的影响 （重庆医科大学附属大学城医院全科，重庆 400050，2.重庆医科大学附属第一医院消化内科，重庆 400016，3.重庆邮电大学生物信息学院，重庆 400065） 观察雷贝拉唑对功能性消化不良（unctional dyspepsia, FD）患者餐后不适综合征（ostprandial distress syndrome, PDS）和上腹疼痛综合征（pigastric pain syndrome, EPS）临床症状、胃电和胃阻抗的影响。对31例FD患者行症状分型和评分，采用阻抗式胃动力检测仪检测餐后胃电和胃阻抗，经雷贝拉唑10mg qd治疗2周后，再次症状评分并复查胃电及胃阻抗。治疗2周后，PDS组和EPS组上腹痛和上腹烧灼感2个症状显著改善（P＜0.05），EPS组除上述2个症状显著改善外，餐后饱胀不适也有显著改善（P＜0.05）。治疗前后PDS组胃电中频百分比分别为 [（53.74±7.41）%，（56.62±6.24）%]，高频百分比分别为[（23.31±3.72）%，（20.88±4.26）%]，治疗前后EPS组胃电中频百分比分别为 [（51.03±6.13）%，（55.85±4.66）%]，高频百分比分别为[（23.87±4.00）%，（20.97±3.49）%]，治疗前后两组胃电中频和高频百分比均有显著差异（P＜0.05），但两组治疗前后胃阻抗各频次均无显著性差异（P＞0.05）。经雷贝拉唑治疗2周可改善PDS组和EPS组与酸相关的临床症状和部分胃电，EPS组效果更明显，胃阻抗无显著变化。 功能性消化不良；雷贝拉唑；阻抗式胃运动 Effects of Rabeprazole on impedance gastric motility of patients with functional dyspepsia LUO Fang1，LIU Chunlun2，LI Zhangyong3 （1. Department of general practice, university-town hospital of Chongqing Medical University；2.Departiment of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University；3.College of Bioinformation, Chongqing University of Posts and Telecommunications.） 【Abstract】Objective: To observe the effects of Rabeprazole on symptom, electrical signal and impedance gastric motility of the patients with functional dyspepsia who was classified as PDS(postprandial distress syndrome) and EPS(epigastric pain syndrome) group according to Rome Ⅲ. Methods: 31 patients with functional dyspepsia were collected. The electrical signal and impedance signal were collected at the same time. Symptoms of patients with FD were scored before and after treatment with Rabeprazole(10mg,qd) for 2 weeks. The postprandial gastric motility was tested repeatedly for comparison. Results: After 2 weeks treatment, Rabeprazole can significantly improve symptoms of postprandial abdominal distention, upper abdominal pain and abdominal burning sensation in EPS group, and upper abdominal pain and abdominal burning sensation in PDS group(P＜0.05). After 2 weeks of trea