ppt课件-class ipathway predictionofproteasomalcleavageand t a p（类ipathway predictionofproteasomalcleavageand t p）.pptVIP

Class I pathwayPrediction of proteasomal cleavage and TAP binding Outline MHC class I epitopes Antigen processing Proteasome Specificity and Polymorphism Prediction methods TAP Binding motif Evolution Immune escape Peptide generation in the class I pathway Proteasomal cleavage Proteasome specificity Low polymorphism Constitutive Immuno-proteasome Evolutionary conserved Stochastic and low specificity Only 70-80% of the cleavage sites are reproduced in repeated experiments Proteasome evolution (b1 unit) Immuno- and Constitutive proteasome specificity Immuno- and Constitutive proteasome sp