呼吸衰竭诊断指标及救治措施高建苑__培训课件.pptVIP

Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprin