西酞普兰与麦普替林治疗老年抑郁症对照研究.docVIP

西酞普兰与麦普替林治疗老年抑郁症对照研究 【关键词】 老年抑郁症；西酞普兰；麦普替林；汉密顿抑郁量表；疗效 　　【摘要】 目的 探讨西酞普兰与麦普替林治疗老年抑郁症的临床疗效及安全性。 方法 将66例老年抑郁症患者随机分为两组各33例，研究组给予西酞普兰治疗，对照组给予麦普替林治疗，疗程6w。采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。 结果 两组治疗1 w、2 w末汉密顿抑郁量表评分均较治疗前显著下降（P＜0.05或0.01），研究组较对照组下降显著（P＜0.01或0.05）；治疗6 w末研究组显效率81.8%，总有效率93.9%；对照组分别为75.8%，87.9%。两组总体疗效相当（P＞0.05），但研究组不良反应较对照组发生率低，且程度轻，差异有显著性（P＜0.05）。 结论 西酞普兰治疗老年抑郁症起效快，疗效显著，安全性高，依从性好。 　　【关键词】 老年抑郁症；西酞普兰；麦普替林；汉密顿抑郁量表；疗效 　　A Control Study of citalopram and maprotiline senile depression 　　【Abstract】 Objective To explore the clinical efficacy and security of citalopram and maprotiline in the treatment of senile depression. Methods 66 patients with senile depression were randomly divided into research group(n=33,took citalopram) and control group(n=33,did maprotiline) for six weeks. The clinical efficacy was assessed with the Hamilton Depression Scale (HAMD)and adverse effect with the Treatment Emergent Symptom Scale (TESS). Results Compared with pretreatment, at the ends of the 1st and 2nd week the HAMD scores of both 2 groups descended significantly(P＜0.05 or 0.01),and decrease was more significant in the research group than in the control(P＜0.01 or 0.05); at the end of 6th week treatment, effectual and total effective rate was 81.8% and 93.9% in the research group and 75.8% and 87.9% in the control group. The total curative effects of the 2 groups were equivalence(P＞0.05); incidence of adverse effects was lower and degree milder in the research group than in the control, differences were significant(P＜0.05). Conclusion Citalopram takes effect faster and has significant curative effect, higher safety and better compliance in the treatment of senile depression. 　　【Keywords】 Senile depression; citalopram; maprotiline; the HAMD; curative effect 西酞普兰是一种高选择性5羟色胺（5HT）再摄取抑制剂［1］。国内外研究［2,3］表明该药治疗抑郁症安全有效。为此，我们采用西酞普兰治疗老年抑郁症与麦普替林进行了对照研究，探讨西酞普兰治疗老年抑郁症的疗效及安全性，现将结果报告如下。 　　1 对象与方法 　　1.1 对象 选取2003年10月～2005年11月在我院门诊及住院治疗的老年抑郁症患者为研究对象。入组标准：（1）符合《