2017整理chapter 11 CYTOKINE AND CYTOKINE RECEPTOR forclass.ppt

银屑病中CXCR1及CXCR2表达增高 白细胞介素-8受体1型和2型在强直性脊柱炎中均高表达 member receptors Secrete receptor Section 3 Cytokine receptor Section 4 Biological effects of cytokines 1 Regulate immunocyte differentiation and maturation 2 Mediate innate immunity 3 Mediate adaptive immunity 4 Stimulate haematogenesis 5 Cytokine and tumor The role of IL-8 signaling in the tumor microenvironment. Tumor-derived IL-8 has the capacity to exert profound effects on the tumor microenvironment. For example, secretion of IL-8 from cancer cells can enhance the proliferation and survival of cancer cells through autocrine signaling pathways. In addition, tumor-derived IL-8 will activate endothelial cells in the tumor vasculature to promote angiogenesis and induce a hemotactic infiltration of neutrophils into the tumor site. Although IL-8 can promote cell invasion and migration, the capacity of IL-8 to induce tumor-associated macrophages to secrete additional growth factors will further increase the rate of cell proliferation and cancer cell invasion at the tumor site. 6 Cytokines and immunological disorders (1) Transplantation rejection X-linked SCID, (XSCID) (2) Immunodeficiency Mutations in the ? c ( common ? chain) chain of the receptors for interleukins IL-2, -4,-7,-9 and -15 **Signal transduction , **lymphocyte differentiation, proliferation and maturation IL-2R IL-4R IL-7R IL-9R IL-15R common ? chain In the 1990s, late ? researchers tested a gene therapy treatment that would restore the function of a crucial gene, gamma c, to cells of the immune system. This treatment appeared very successful, restoring immune function to most of the children who received it. bubble boy disease, 有γ链细胞因子受体图解含有γ链的细胞因子受体损伤或缺失导致下游信号传导受阻引起SCID病。γ链是IL-2、IL-4、IL-7、IL-9、IL-15和IL-21受体的组成成分。其中，IL-2R、IL-15R有三个亚基：α、β、γ；IL-4R、IL-7R、IL-9R和IL-21R由α、γ亚基组成。若没有γ链，正常信号传导途径--JAKs激活、信号使者磷酸化、STAT蛋白激活受阻。至今研究确定SCID的起因包括γ链损伤和表达的γ链无功能、表达的JAK蛋白无功能（不能被激活去磷酸化STAT分子）或者是IL-7Rα链缺陷。简单起见，图示的受体为两个亚基组成（如IL-7R）。 SCID-X疾病体内基因治疗的原理CD34+