Neuralsubstratesforexpectation-modulatedfearlearningin.pptVIP

Neural substrates for expectation-modulated fearlearning in the amygdala and periaqueductal gray Joshua P Johansen, Jason W Tarpley, Joseph E LeDoux Hugh T Blair INTRODUCTION The amygdala is an important site of neural plasticity, where associative memories are stored during fear conditioning. Storage of fear memories requires Hebbian long-term potentiation at conditioned stimulus input synapses onto neurons in the lateral nucleus of the amygdala. This Hebbian plasticity may cause postsynaptic depolarization of lateral nucleus of the amygdala (LAn) neurons in conjunction with presynaptic