肾上腺素受体激动药.ppt-AdrenoceptorAgonists.pptVIP

definition Drugs that mimic the actions of epinephrine or norepinephrine Sympathomimetic drugs Classification Depend on the affinity for different groups of receptor α-adrenoceptor agonists β-adrenoceptor agonists α, β-adrenoceptor agonists Chemistry Parent compound: phenylethylamine Change the affinity for α or β receptors Change pharmacokinetics properties Chemistry and pharmacokinetics Substitutions On the terminal amino group: increase β receptors activity On the benzene ring: increase bioavailability and prolongs the duration of action; increase the distribution of molec