功能化磁性纳米粒子论文功能化磁性纳米硅胶粒子的制备表征及应用研究.docVIP

功能化磁性纳米粒子论文：功能化磁性纳米硅胶粒子的制备、表征及应用研究 【中文摘要】本论文设计合成并表征了一些新颖的含N,O,S等杂原子的化合物及其与过渡金属配位的配合物,并将这些配合物修饰到硅胶包覆的磁性纳米粒子表面。我们利用了SEM, TEM, FTIR, TGA和XRD等手段进行了表征。研究内容主要分为三个部分：首先,利用二价铁和三价铁在碱性水中共沉淀制备得到尺寸约为10纳米的Fe3O4(MNPs)磁性纳米粒子,再利用Philipse法将TEOS在碱性条件下水解把MNPs做为核中心在它的外层进行二氧化硅包覆,得到核壳式的Fe3O4@SiO2磁性纳米粒子。其次,合成了一系列含N,O,S等杂原子配体,例如：化合物二-(吡啶-2-甲基)胺(DPA)6、二(2-(毗啶-2-甲基硫代)乙基)胺16、2,6-双(哌嗪-1-甲基)苯酚25的以及2,6-二((4-苄基哌嗪-1-基)甲基)苯酚30的合成。研究了配体6和16与过渡金属离子Cu2+的配位,还合成配体L和它的汞的配合物,并得到[HgL(C104)的晶体结构,这些化合物都进行了红外、紫外和核磁等表征。最后,将配体6与Cu2+作用所得的化合物修饰到硅胶包覆的磁性纳米粒子表面。所得到的功能化磁性纳米粒子可以用于从牛血清中吸附分离和提纯牛血清白蛋白,具有高的选择性和很好的吸附效率,这种材料的优点是合成简单、处理方便、操作过程简便、分离效果显著,更重要的是还可以回收和重复使用、成本低廉。我们将继续把配体25和30与过渡金属作用所得的化合物修饰到磁性纳米粒子表面,研究并挖掘它们在其它领域的应用及潜在价值。 【英文摘要】In this dissertation, some novel multi-dentate ligands containing N, O or S heteroatom and their transition metal coordination complexes were synthesized and characterized, and these compounds were modified on the surface of silica coated magnetic nanoparticles. SEM, TEM, FTIR, TGA and XRD as well as other technologies were used to investigate the figure, size, structure, chemical composition, and magnetic properties of the functional materials. This research consists mainly of three chapters.Firstly, Iron oxide magnetic nanoparticles (MNPs) and silica-coated magnetic nanoparticles (Fe3O4@SiO2) were prepared by the chemical coprecipitation and the method of Philipse. SEM and TEM showed that Fe3O4@SiO2 with an average size of 110 nm and MNPs with an average size of 10 nm。Secondly, synthesis and characterization of multi-dentate ligands bis(pyridine-2-ylmethyl)amine(6), bis(2-(pyridin-2-ylmethylthio)ethyl)amine (16), 2,6-bis(piperazin-1-ylmethyl)phenol (25) and 2,6-bis((4-benzylpiperazin-1-yl) methyl) phenol (30) were described. These compounds were fully characterized using UV-vis, IR and microanalysis.Finally, the functionalized silica-coated magnetic nanoparticles (MFMNPs) were applied to adsorption and separation of the BSA with chemistry binding. In addition, the direct separation BSA w