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The Radiology Assistant
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Multiple Sclerosis
by Frederik Barkhof and Robin Smithuis
From the MR Center for MS Research, Radiology Department of the Vrije Universiteit Medical Center, Amsterdam and the Rijnland Hospital, Leiderdorp, the Netherlands
Introduction
Multiple sclerosis
Typical MRI findings in MS
Dawson fingers
Mc Donald criteria for MS
MRI protocol
MS Brain Protocol
MS Spinal cord Protocol
Prevalence and a priori chance
Reporting
Differential diagnosis of WMLs
DD multiple patchy lesions
DD multiple enhancing lesions
Virchow Robin spaces
Normal Aging
Vascular disease
Sarcoid
Lyme disease
HIV
Cadasil
Addendum
2005 Revised McDonald MS Diagnostic Criteria
Fazekas classification back to overview??? print
Publicationdate:
1-2-2007
This review is based on a presentation given by Frederik Barkhof at the Neuroradiology teaching course for the Dutch Radiology Society and was adapted for the Radiology Assistant by Robin Smithuis. This presentation will focus on the role of MRI in the diagnosis of Multiple Sclerosis.We will discuss the following subjects:
Typical findings in MS
Role of MR in the McDonald criteria of MS
How to differentiate MS lesions from other white matter diseases
The importance of the a priori chance for the differential diagnosis of white matter lesions. ? Introduction
Multiple white matter lesions. MS or vascular? One of the most common questions in daily radiology practise, when we see an image like the one on the left is: Do we have to think of Multiple Sclerosis or are these white matter lesions the result of small vessel disease, for instance in a hypertensive patient or should we think of more uncommon diseases?
In order to be able to answer that question, we have to realise that when we study white matter lesions (WMLs):
Many neurological diseases can mimic MS both clinically and
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