生物制药基因工程药物幻灯片.pptVIP

Chemical mediators Released by platelets Platelets cover and adhere to exposed subendothelial surface + Activation of coagulation factors in plasma Prothrombin (II) Thrombin (IIa) Fibrinogen(I) Fibrin 1 2 3 4 Formation of a hemostatic plug Damage to vessel expose collagen to subendothelium Platelet adhesion and release of granules Platelet aggregation and formation of fibrin plug 1 3 2 TXA2 TXA2 Aspirin AA PGG2, PGH2 Platelet TXA2 binds to receptors on other platelets thereby initiating release of additional aggregating agents. DAG IP3 ATP cAMP 5`-AMP Dipyridamole PGI2 5-HT ADP Balance between