福斯利诺安全性.pptVIP

Lanthanum Metabolism Basis * 3369 * * * * * * 解说词： 肝脏是被人体少量吸收的镧代谢的主要途径，那么镧会不会影响正常肝功能呢？ 对大鼠大剂量（镧：1500/2000 mg/kg/d, ）研究显示：肝脏镧水平只在服用碳酸镧一开始有少量增加，在服用12-26周后趋于平稳，并且各个检测时期肝脏中镧含量均未超过2.7 μg/g。同时，研究结果还显示，服用碳酸镧治疗组大鼠的ALP、AST和ALT活性与标准治疗组间无显著差异，组织学检测也未见镧引起的不良反应发生。 In a study conducted using a rat model of chronic renal failure, deposition of lanthanum was detected at the outer edge of mineralised bone, following oral administration of 2000 mg/kg/day lanthanum carbonate for 12 weeks.17 ? Local lanthanum concentrations in bone have been estimated to be equivalent to replacing one out of every 2000 calcium at