zhangxiaohongdepartmentofinfectiousdiseasessunyat-.pptVIP

A NEWS REPORT The news report From the Yangcheng evening news paper 25 SEP 2000 In Fujian province A 27 year old young man Xu, went to the hospital because of chills and fever The doctor made a diagnosis as leptospirosis After the patient had been injected PG and Virazole, the doctor let him back home. Leptospirosis General Review Etiology Epidemiology Pathogenesis and Pathology Clinical Manifestations Diagnosis Treatment and Prevention Etiology: Morphology Thin, flexible, finely coiled with a hook at the ends Gram-Negative, Giemsa stain: Light red 0.1μm in diameter 6-20μm in length Etiology: Picture (dark-field microscope) Motility can be seen It is characterized by very active motility, by roating and bending Etiology: Culture Obligate aerobic, slow growing Cultured in Korthol media enriched with rabbit serum or albumin, at 30 ℃ and an optimal PH 7.2 to 7.6， their generation time varies from 7 to 12 hours It can be isolated by intraperitoneally inoculating of young guinea-pig Etiology: Resistance It is sensitive to dry, suds, ethanol and bleaching powder Survive in damp soil and water for 4wks-3mths Etiology: Classfication 23 Serogroups, 200 serotypes 19 Serogroups and 74 serotypes in China The most common serogroups: L. icterohemorrhagic(黄疸出血群) L. pomona(波摩那群) L. canicola(犬群) L. hebdomadis(七日热群) Widest distribution in China : L.pomona L. icterohemorrhagic causes the most severe illness Epidemiology In 1886, Weil, a German doctor observed 4 cases of leptospirosis with jaundice, than this disease is called as Weil disease In China: in 1937, Professor Tang zeguang (汤泽光)discovered leptospirosis in Guangzhou Epidemiology： Source of Infection Reservoirs of infection: rodents, domestic livestock (swine and cattle), dogs and foxes Source of infection Livestock：swine,dogs, cattle,sheep,horses Wild animals：rats(Apodemus agarius,黑线姬鼠), rabbits,wolfs,snakes and frogs  The main source of Infection： Apodemus agariu: L.icterohemorrhagic. Fi