同步放化疗治疗中晚期宫颈癌的临床疗效观察.docVIP

同步放化疗治疗中晚期宫颈癌的临床疗效观察 　　doi：10.3969/j.issn.1007-614x.2014.14.28 　　摘 要 目的：观察同步放化疗治疗中晚期宫颈癌的疗效及安全性。方法：将收治的中晚期宫颈癌患者80例随机分为两组，单纯给予放疗40例为放疗组，给予同步放化疗40例为放化组。结果：放化组总有效率90.0%，显著高于放疗组的77.5%，P0.05；两组第1年生存率比较差异无统计学意义，但第3年生存率放化组显著高于放疗组，P0.05；放化组不良反应显著高于放疗组（P0.05），但均可耐受。结论：同步放化疗治疗中晚期宫颈癌可提高近期疗效，其不良反应较单纯放疗增加，但不影响放疗进程，患者能耐受。 　　关键词 中晚期宫颈癌 同步放化疗 疗效 　　Observation of the clinical curative effect of radiotherapy and chemotherapy in the treatment of advanced cervical cancer 　　Yan Shichun 　　The seconed department of tumor of the hospital of traditional Chinese Medicine of Laizhou City in Shandong Province，261400 　　Abstract Objective：To observe the efficacy and safety of radiotherapy and chemotherapy in the treatment of advanced cervical cancer.Methods：80 cases of advanced cervical carcinoma were randomly divided into two groups.40 cases treated with radiotherapy were radiotherapy group，and another 40 received the concurrent chemoradiotherapy were radiotherapy and chemotherapy group.The two groups had the same radiotherapy plan.Results：The radiotherapy and chemotherapy group total effectiveness was 90%，significantly higher than that of radiotherapy group 77.5%，P0.05.The two groups of first years survival rate was not significant，but the third year survival rate of the radiotherapy and chemotherapy group was significantly higher than that of radiotherapy group，P0.05. Adverse reaction of radiochemical and chemotherapy group was significantly higher than that in the radiotherapy group（P0.05），but all patients could tolerate.Conclusion： Radiotherapy and chemotherapy for advanced cervical cancer may improve short-term curative effect.The adverse reactions of radiotherapy and chemotherapy increases，but it does not affect the process of radiotherapy，and the patients can tolerate. 　　Key words In advanced cervical cancer；Concurrent chemoradiotherapy；Curative effect 　　宫颈癌是女性常见恶性肿瘤之一，中晚期宫颈癌传统治疗首选放射治疗，虽然放射治疗技术日益先进，但患者常因远处转移和局部复发导致治疗失败，且单纯放疗对提高生存率无明显帮助，5年生存率仅30%～50%[1]。为了提高中晚期宫颈癌的疗效与远期生存率，本研究