彩色多普勒超声检测α重型地中海贫血胎儿大脑中动脉的价值研究.docVIP

彩色多普勒超声检测α重型地中海贫血胎儿大脑中动脉的价值研究 　　[摘要] 目的 探讨应用彩色多普勒超声检测大脑中动脉（MCA）预测胎儿α重型地中海贫血的临床价值。 方法 将在本院接受产前检查，夫妇双方经血液学检查为α地中海贫血基因携带者130例（观察组）和正常对照组130例胎儿，进行产前彩色多普勒超声检查，常规超声检查后，对胎儿MCA的收缩期峰值血流速度（PSV）进行测量记录，并通过羊膜腔穿刺或脐血穿刺术进行地中海贫血基因诊断，行脐血穿刺术者做胎儿血红蛋白（Hb）测定。 结果 重型α地中海贫血胎儿的MCA-PSV明显增高，并同中间型、轻型、无α地中海贫血组及对照组胎儿比较，差异有统计学意义（均P0.05）。 结论 彩色多普勒超声目前是测量α重型地中海贫血胎儿MCA的一种非侵入性方法，是一种具有重复性好、安全、无创且经济实用特点的有效诊断方法。 　　[关键词] 大脑中动脉；胎儿；地中海贫血；彩色多普勒超声 　　[中图分类号] R556.9[文献标识码] A[文章编号] 1674-4721（2014）06（a）-0107-03 　　 　　Study of value of color Doppler ultrasound detecting middle cerebral artery in fetuses with α severe Mediterranean anemia 　　CHEN Xiao-lan 　　Department of Medical Technology,Luoding Traditional Chinese Medicine Hospital in Yunfu City of Guangdong Province,Yunfu 527200,China 　　[Abstract] Objective To explore the clinical value of color Doppler ultrasonic detecting middle cerebral artery (MCA) in fetuses with alpha severe Mediterranean anemia. Methods 130 cases with alpha Mediterranean anemia gene carriers (the observation group) whose patients examined by hematology and whose mother receiving prenatal examination in our hospital,and 130 normal fetuses were selected as the control group,color Doppler ultrasound examination was carried out in all of fetuses,after routine ultrasound examination,peak systolic velocity (PSV) of blood flow of MCA in fetuses was measures and recorded.Thalassemia gene was diagnosed by amniocentesis or cordocentesis,hemoglobin (Hb) was detected in whom taken umbilical cord puncture. Results MCA-PSV increased obviously in fetuses with severe alpha Mediterranean anemia,and there was statistical difference of MCA-PSV between the fetuses with severe alpha Mediterranean anemia and the intermediate type,light,no Mediterranean anemia group,the control group (all P0.05). Conclusion Color Doppler ultrasound is a non-invasive method detecting MCA of fetuses with alpha severe Mediterranean anemia,and it is an effective diagnostic method of having the characteristics of good rep