心脏动物模型简析.pptVIP

生理学教研室 徐明 Animal Models for Hypertension Aetiology of Hypertension Primary(essential or idiopathic) – 90-95% of cases Secondary – about 5% of cases Renal or renovascular disease（肾/肾血管疾病） Endocrine disease Pheochromocytoma（嗜铬细胞瘤） Cusings syndrome（库兴氏综合症） Conn’s syndrome（醛固酮腺瘤） Acromegaly and hypothyroidism Coarctation of the aorta（主动脉狭窄） Iatrogenic（医源性） Hormonal / oral contraceptive（激素/口服避孕药） NSAIDs（非甾体抗炎药） Fig 1. Categories of animal models of hypertension. The genetic models include those that are phenotype-driven (eg, SHR) or genotype-driven (eg, null mice). The nongenetic models include