Cell-2016-Evidence for Pro-angiogenic Functions of VEGF-Ax英文书.pdf

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Cell-2016-Evidence for Pro-angiogenic Functions of VEGF-Ax英文书.pdf

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Matters Arising Evidence for Pro-angiogenic Functions of VEGF-Ax Graphical Abstract Authors Hong Xin, Cuiling Zhong, Eric Nudleman, Napoleone Ferrara Correspondence nferrara@ In Brief Contrary to a previous report, VEGF-Ax does not possess anti-angiogenic properties. Highlights d VEGF-Ax does not inhibit endothelial cell growth and angiogenesis d VEGF-Ax has mitogenic, angiogenic, and permeability- enhancing functions d The mitogenic effect of VEGF-Ax is less potent than VEGF165 d The lower potency of VEGF-Ax is consistent with its inability to bind Neuropilin-1 Xin et al., 2016, Cell 167, 275–284 September 22, 2016 a 2016 Elsevier Inc. /10.1016/j.cell.2016.08.054 Matters Arising Evidence for Pro-angiogenic Functions of VEGF-Ax Hong Xin,1 Cuiling Zhong,1 Eric Nudleman,1 and Napoleone Ferrara1,2,* 1University of California, San Diego, 3855 Health Sciences Drive #0819, La Jolla, CA 92093, USA 2Lead Contact *Correspondence: nferrara@ /10.1016/j.cell.2016.08.054 SUMMARY common isoforms have been reported, including VEGF145 and VEGF183 (Ferrara, 2