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Notch signaling and colorectal cancer 卜晓东 Department of Pathology, SEU Introduction The biological role of Notch signaling as a regulator for cell differentiation was first identified in 1937, but its role in cancer was not recognized until 1991 when Notch1 was suspected to be casually related to the development of T-cell acute lymphocytic leukemia (T-ALL)/lymphoma . The discovery of the role of ?-secretase in the Notch signaling activation in 1999 had prompted intensive research on the potential application of ?-secretase inhibitors in the treatment of various cancers. It is now recogniz