Introduction.选编.ppt

组成：淋巴结、脾、粘膜免疫系统 第二节 外周免疫器官 （peripheral immune organ） Lymph node Spleen Mucosal Associated Lymphoid Tissue ( MALT) 功能：成熟的Ｔ细胞、Ｂ细胞定居的地方， 也是产生免疫应答的部位 The sites where mature T and B cells residence. The sites where adaptive immune responses to foreign antigens are initiated and develop. 数量：500－600个 分布：广泛分布于全身非粘膜部位的淋巴通道上 I. Lymph node ( LN) 淋巴结 Structure: Cortex Lymphoid follicle ( Thymus-independent area) Paracotical area (Thymus-dependent area) medulla medulla cords: macrophage and plasma cells medulla sinus Figure 1-8 part 1 of 2 Function of lymph node *Sites of mature T and B residence *Sites of immune response initiated *Participate in lymphocyte recirculation *Filter and discharge of antigen Lymphatic System 淋巴系统 脾（spleen）--- 人体最大的免疫器官 动脉周围淋巴鞘 红髓 白髓 初级滤泡 中央动脉 脾的结构 (Structure of Spleen) Functions: 1) site of T and B cells residence 2) undergo immune response 3) produce IFN, complement 4) filter the blood 皮肤黏膜相关淋巴组织 皮肤相关淋巴组织 （Skin-associated lymphoid tissue） （Skin and mucosal-associated lymphoid tissue） （Skin and mucosal-associated lymphoid tissue） 黏膜相关淋巴组织（MALT） MALT的功能及其特点 参与黏膜的局部免疫应答 产生分泌型 IgA 参与黏膜局部免疫应答 产生分泌型IgA 成熟淋巴细胞离开中枢免疫器官后，经血液循环趋向性迁移并定居于外周免疫器官或组织的特定区域，称为淋巴细胞归巢（lymphocyte homing）。 淋巴细胞归巢与再循环 淋巴细胞在血液、淋巴液、淋巴器官或组织间反复循环的过程称为淋巴细胞再循环（lymphocyte recirculation）。 lymphocyte homing and lymphocyte recirculation It enables the limited number of lymphocytes in an individual that are specific for a particular foreign antigen to search for that antigen throughout the body. It ensures that particular subsets of lymphocytes are delivered to the particular tissue where they are required for adaptive immune responses and not,wastefully,to places where they would serve no purpose. Recirculation of memory cells promote secondary immune responses efficiently. Fulfill lymphocyte tissues with circulated lymphoctes Significance of lymphocytes recirculation 1.What are the primary and secondary lymphoid organs? Wh