Fibrous Dysplasia Loma Linda University Medical 骨纤维异常增殖症洛玛连达大学医学.pptVIP

Fibrous Dysplasia Jan M. Eckermann, MD Department of Neurosurgery Definition Benign condition in which normal bone is replaced by fibrous connective tissue due to a defect in osteoblast differentiation and maturation Epidemiology Incidence not known Females males No race predilection Initial symptoms manifest age 3-15 Not heritable Questionable genetic transformation Malignant transformation in 1% Variations Cystic (21%) Radiolucency surrounded by solid rim Sclerotic (23%) Dense and homogenous Mixed (56%) “Ground glass appearance” Variations, cont’d Monostotic Most common 25% involve hea