Incomplete penetrance University of Michigan Health 不完全外显率密歇根大学健康.pptVIP

Population GeneticsandMultifactorial Inheritance 2002 Consanguinity Genetic drift Founder effect Selection Mutation rate Polymorphism Balanced polymorphism Hardy-Weinberg Equilibrium Hardy-Weinberg Equilibrium Explains why, In a large population with random mating: 1. Allele frequencies do not change from generation to generation 2. Genotype frequencies are determined by allele frequencies at that locus Allele frequencies in X-linked disorders Males are hemizygous for the X-chromosome: therefore frequency of affected males = frequency of the mutant allele, q For rare XLR disorders, fre