Leech Heart Half Center Oscillator Drexel University水蛭半心中心振荡器卓克索大学.pptVIP

Leech Heart Half-Center Oscillator: Control of Burst Duration by Low-Voltage Activated Calcium Current Introduction Half-center oscillators, also called central pattern generators (CPG), drive rhythmic behaviors Burst Period = Burst Duration + Interburst Interval Burst period varies depending on functional demand of activity (ex. Heart rate, breathing rate, locomotion speed…) Bursting is maintained by slowly inactivating inward currents Leech Heart CPG A pair of mutually inhibitory neurons Burst duration is controlled by both, the bursting neuron itself and the opposite neuron Each neuron on i