06表观遗传学课件.pptVIP

* * * * * * * * * * Epigenetic modifications leading to gene transcriptonal regulation. TF: transcriptional factors; DNMT: DNA methyltransferase; HAT: Histone acetyltransferase; HDAC: Histone deacetylase; MBP: Methyl-CpG binding protein; HMT: Histone methyltransferase. Modifications of the histone H3 tails, Lys4 (K4) and Lys9 (K9), are indicated. Ac: acetylation; Me: methylation * Epigenetic differences arise in MZ twins. (A) Two representative examples of the determination of monozygosity using microsatellite markers. (B) Quantification of X chromosome inactivation by PCR amplification of th