抗多药耐药靶点及相关药物的进展_吴晨解剖.pdf

829PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 11 :829-840     Research Progress in Therapeutic Targets for Multidrug Resistance and Related Drugs WU Chen, XU Zhuxuan, ZHOU Qimeng, ZHI Yunbao, LIN Kejiang ( Department of Pharmacy, China Pharmaceutical University, Nanjing 210009, China) Multidrug resistance (MDR) refers to the process in which cells produce wide resistance to a variety of drugs, leading to unsatis?ed treatment. Multidrug resistance mainly occurs in treatment of infections and cancers, which greatly restricts the therapeutic effects on both diseases. The research progress of anti-MDR mechanisms and drugs based on the receptor types, including transport proteins, ion channels, enzymes and ribosomes, has been reviewed in this paper, so as to provide references for the development of anti-MDR drugs. multidrug resistance; infection; tumor; transporter; enzyme; ribosome protein Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 830 Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 831 Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 832 Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 833 FolP Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 834 SUL2 SUL1 SUL2 SUL1 Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 Klebsiella pneumoniae 835 t ζ ζ Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 836 c-JUN c-FOS δ ? Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 837 erm erm(C) erm(A) erm erm(B) erm(C) erm(F) erm(F) erm(B) erm erm(A) Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 838 Prog Pharm Sci Nov. 2014 Vol. 38 No. 11 839 [1] Szakács G, Paterson J K, Ludwig J A, et al. Targeting multidrug resistance in cancer [J]. Nat Rev Drug Discov, O 20N06, 5 (3): 219-234. [2] Higgins C F. ABC transporters: from microorganisms to man [J]. Annu O Rev Cell Biol, 1992, 8: 67-113. NN H [3] Chang G, Roth C B. Structure of MsbA from E. coli: a homolog of the multidrug resistanceNATP bOinding cassette (ABC) transporters [J]. Science, 2001,N293 (5536N): 1793-1800. [4] Dean M, RzhetskOy A, Allikmets R. The human AT