稳心颗粒联合美西律片治疗快速性心律失常的临床疗效评价.docVIP

稳心颗粒联合美西律片治疗快速性心律失常的临床疗效评价 　　【摘要】 目的 探讨稳心颗粒联合美西律片治疗快速性心律失常的临床有效性及安全性。方法 130例快速性心律失常患者， 根据随机原则分为对照组和治疗组， 每组65例。对照组给予美西律片进行治疗， 治疗组给予稳心颗粒联合美西律片进行治疗。治疗4周后观察两组患者治疗后的临床症状疗效及心电图变化等， 对其疗效性指标和安全性进行评价。结果 治疗组和对照组治疗后临床症状疗效比较， 治疗组总有效率为93.8%， 高于对照组的72.3%， 差异有统计学意义（P0.05）；治疗组和对照组治疗后心电图变化疗效比较， 治疗组总有效率为95.4%， 高于对照组的69.2%， 差异有统计学意义（P0.05）。结论 临床运用稳心颗粒联合美西律片治疗快速性心律失常能有效的改善患者心悸、胸闷、失眠等临床症状， 且安全性良好。 　　【关键词】 稳心颗粒；美西律片；快速性心律失常；安全性 　　DOI：10.14163/j.cnki.11-5547/r.2016.09.001 　　Evaluation of clinical effect by Wenxin granules combined with mexiletine tablets in the treatment of tachyarrhythmia SUN Ya-chao， ZHENG Hai-jun. Henan Jiaozuo City People’s Hospital， Jiaozuo 454000， China 　　【Abstract】 Objective To investigate clinical effect and safety by Wenxin granules combined with mexiletine tablets in the treatment of tachyarrhythmia. Methods A total of 130 patients with tachyarrhythmia were randomly divided into control group and treatment group， with 65 cases in each group. The control group received mexiletine tablets for treatment， and the treatment group received Wenxin granules combined with mexiletine tablets for treatment. Observation was made on clinical symptoms and electrocardiogram changes before and after treatment in both groups after 4 weeks of treatment. Their curative effect indexes and safety were evaluated. Results The treatment group had higher total effective rate as 93.8% than 72.3% of the control group in clinical symptoms effect after treatment， and their difference had statistical significance （P0.05）. The treatment group also had higher total effective rate in electrocardiogram changes before and after treatment as 95.4% than 69.2% of the control group， and their difference had statistical significance （P0.05）. Conclusion Clinical application of Wenxin granules combined with mexiletine tablets can effectively improve symptoms of palpitation， chest distress and insomnia in the treatment of tachyarrhythmia， along with good safety. 　　【Key words】 Wenxin granules； M