preliminaryevaluationofthepotentialriskstoconsumersof.docVIP

Preliminary evaluation of the potential risks to consumers of animal-derived food products following non-authorised veterinary use of chemicals FINAL REPORT March 2007 The Institute of Environment and Health was established at Cranfield University in November 2005. The Institute is principally funded by UK Government Departments and Agencies by way of specific research and consultancy contracts. The views expressed here do not necessarily represent those of any Government Department or Agency. This document is a Final Report by the Institute of Environment and Health and the Central Science Laboratory for the Department for Environment Food and Rural Affairs. Prepared by P Holmes1, LS Levy1, L Assem1, A Boxall3, M Litchfield2, Jane Cotterill3, Qasim Chaundhry3 M Taylor3 1 Institute of Environment and Health, Cranfield Health, Cranfield University2 Consultant 3 Central Science Laboratory The authors gratefully acknowledge the contributions made to the conduct of the project, and to the preparation of early drafts of the report, by E Stutt, J Massey, L Shuker, P Rumsby and C Courage while at the MRC Institute for Environment and Health (Institute of Environment and Health, 2007 Institute of Environment and HealthCranfield HealthCranfield UniversitySilsoeBedfordshireMK45 4DTUK Central Science LaboratorySand HuttonYorkYO41 1LZ Contents Page No. Executive Summary 1 1 Introduction 3 2 Methodology 6 2.1 Exposure and risk assessment 6 2.2 Hazard assessment 9 3 Evaluations 12 3.1 Chloramphenicol 12 3.2 Clenbuterol 13 3.3 Dimetridazole 13 3.4 Enrofloxacin 14 3.5 17?-Estradiol 14 3.6 Flavomycin 15 3.7 Furazolidone 15 3.8 Lasalocid sodium 16 3.9 Malachite green 16 3.10 Nalidixic acid 17 3.11 Nandrolone 17 3.12 Narasin 18 3.13 Phenylbutazone 18 3.14 Progesterone 18 3.15 Salbutamol 19 3.16 Streptomycin 19 3.17 Testosterone 20 4 Conclusions 29 4.1 Discussion and conclusions 29 4.2 Recommendations 31 5 References 32 Annex 1 Chloramph