结肠癌修改稿.docVIP

结肠癌患者瘤体及外周血ICAM-1和VCAM-1的表达研究 李兆德1,段升军2,王立国1,陈杰1,张晓东1 1济南市槐荫人民医院外科，济南 250021 2济南市第三人民医院 普外科，济南250101 [摘要目的：检测癌对血清中可溶性细胞间附分子（sICAM-l）和可溶性血管细胞附分子（sVCAM-1）进行测定，探讨二者与癌生物学特性预后判断。方法：对32例癌组织、17例炎组织、21例正常组织标本进行ICAM-1及VCAM-1，分析ICAM-1及VCAM-1的表达与癌患者临床病理指标的关系。ELISA对癌外周血进行sICAM-1和sVCAM-1含量的检测，分析前后的变化结果癌组织ICAM-1 VCAM-1的阳性表达率显著高于炎组织及正常组织（P0.05;P0.01）表达水平与患者年龄、性别、肿瘤大小、病理学分级无关（P0.05），与肿瘤分期及有无远处转移有关（P0.05）癌患者血清sICAM-1sVCAM-1水平明显高于炎及正常（P0.05;P0.01）后1周外周血中sCAM-1及sVCAM-1水平比术前显著下降(P0.01;P0.01)结论:可能与癌的浸润转移有关血清sICAM-1、sVCAM-1的检测可能成为监测癌病情进展、治疗效果的有价值指标。 关键词肿瘤细胞间附分子-1血管细胞附分子-1 [中图分类号]R735.3+5 [文献标识码]A [文章编号]1009-9905（2007）03- THE STUDY OF INTERCELLULAR ADHESION MOLECULE-1(ICAM-1) AND VASCULAR CELL ADHESION MOLECULE-1(VCAM-l) EXPRESSIONS IN THE TISSUE AND SERUM OF PATIENTS WITH COLON CANCER Li Zhao-de1,Duan Sheng-jun2,Wang Li-guo1,Chen Jie1,Zhang Xiao-dong1 1.Department of surgery,Jinan Huanyin people’s hospital,Jinan 250021 2.Department of general surgery, Third Peoples Hospital of Jinan,Jinan 250101 [ABSTRACT]Objective:To detect the expressions of ICAM-1 and VCAM-1 in colon cancer tissues,measure the serum soluble intercellular adhesion molecular-l(sICAM-l) and soluble vascular cell adhesion molecular-1(sVCAM-l),study their relations to the biological characterization of colon cancer,to get an objective therapeutic evaluation and judgment of prognosis for patients with colon cancer.Methods:Specimens from 32 colon cancer patients,17 ulcerative colitis patients,21 normal tissues,image analysis with the methods of immunohistochemistry followed.Analysis the correlation between their expressions and clinic pathologic features of colon cancer patients.ELSIA technique was used to measure serum concentration of sICAM-1 and sVCAM-1 befor and post operation in colon cancer patients.Analysis the changes of serum sICAM-1 and sVCAM-1 level.Results:The expressions of ICAM-1 and VCAM-l in colon cancer tissues were significantly higher than that in ulcerative colitis tissues and in normal control group(P