Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome In vitro and in vivo evaluation.pdfVIP

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Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome In vitro and in vivo evaluation.pdf

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Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome In vitro and in vivo evaluation.pdf

Acta Biomaterialia xxx (2017) xxx–xxx Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: /locate/actabiomat Full length article Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In vitro and in vivo evaluation Furqan A. Maulvi a,?, Anjum A. Shaikh a, Dhara H. Lakdawala a, Ankita R. Desai a, Mihir M. Pandya a, Sulabh S. Singhania a, Rutvi J. Vaidya a, Ketan M. Ranch a, Bhavin A. Vyas a, Dinesh O. Shah b,c,d,e a Maliba Pharmacy College, Uka Tarsadia University, Surat 394350, India b Shah-Schulman Center for Surface Science and Nanotechnology, Dharmsinh Desai University, Nadiad 387001, India c Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, United States d Department of Anaesthesiology, University of Florida, Gainesville, FL 32611, United States e School of Earth and Environmental Sciences, Columbia University, New York, NY, United States article info Article history: Received 14 July 2016 Received in revised form 13 January 2017 Accepted 23 January 2017 Available online xxxx Keywords: Hyaluronic acid Contact lenses Implantation Optimization Pharmacokinetic study In vivo ef?cacy study abstract Contact lenses are widely used for ophthalmic drug delivery, but incorporation of drug or formulation in the contact lenses affects its optical and physical property. In the present study, we have designed a novel hyaluronic acid (HA)-laden ring implant contact lenses (modi?ed cast moulding method), to circumvent the changes in critical lens property. The objective was to improve the ocular residence time of HA, by providing sustained ocular HA delivery through implant contact lenses for the treatment of dry eye syndrome. Optimization of HA-implant was carried out using 32 factorial design by tailoring the amount of cross linker and thickness of implant, to achieve sustained HA release with constraint on effective ion diffusivity. The in vivo pharmacokin