Polymorphisms of IFN-γ (+874AT) and IL-12 (+1188AC) in tuberculosis patients and their household contacts in Hyderabad, India.pdfVIP

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Polymorphisms of IFN-γ (+874AT) and IL-12 (+1188AC) in tuberculosis patients and their household contacts in Hyderabad, India.pdf

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Polymorphisms of IFN-γ (+874AT) and IL-12 (+1188AC) in tuberculosis patients and their household contacts in Hyderabad, India.pdf

Human Immunology 77 (2016) 559–565 Contents lists available at ScienceDirect journal homepage: /locate/humimm Polymorphisms of IFN-c (+874A/T) and IL-12 (+1188A/C) in tuberculosis patients and their household contacts in Hyderabad, India Shruthi Thada a,b, Meenakshi Ponnana a, Ramya Sivangala a, Lavanya Joshi a, Madhavilatha Alasandagutti a, Mohd Soheb Sadat Ansari a, Ralf R. Schumann b, Vijayalakshmi Valluri a,c, Sumanlatha Gaddam a,d,? a Bhagwan Mahavir Medical Research Centre, Hyderabad, Andhra Pradesh, India b Institute for Microbiology and Hygiene, Charite University Medical Center, Berlin, Germany c LEPRA India – Blue Peter Public Health Research Centre, Cherlapally, Hyderabad, Andhra Pradesh, India d Department of Genetics, Osmania University Hyderabad, Telangana, India article info Article history: Received 17 November 2015 Revised 12 April 2016 Accepted 20 April 2016 Available online 22 April 2016 Keywords: Tuberculosis Susceptibility Single nucleotide polymorphism IFN-c IL-12 abstract Several cytokine gene variants have shown to be associated with host susceptibility to infectious diseases including tuberculosis (TB). High rates of transmission were identi?ed within household members of TB patients. In this study, we examined whether single nucleotide polymorphisms of IFN-c +874A/T and IL- 12 +1188A/C affect susceptibility to TB. Genomic DNA from patients with active disease, their household contacts HHC and healthy controls HC was genotyped for IFN-c +874A/T and IL-12 +1188A/C SNPs by ampli?cation refractory mutation system-polymerase chain reaction (ARMS-PCR). IFN-c +874 AA and AT genotypes were signi?cantly with different frequencies in patients and total HHC as compared to HC (p 0.0001). In patients IL-12 +1188 AC and CC genotypes were associated with TB (p 0.003, p 0.008). In total HHC AC, CC genotypes and both alleles (AC) were signi?cantly different as compared to HC (p 0.004, p 0.001, p 0.034) and the same result was obtained when HHC were s