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Postnatal maturation of mouse medullo-spinal cerebrospinal fluid-contacting neurons.pdf
Neuroscience 343 (2017) 39–54
POSTNATAL MATURATION OF MOUSE MEDULLO-SPINAL CEREBROSPINAL FLUID-CONTACTING NEURONS
ADELINE ORTS-DEL’IMMAGINE, aà JE′ RO? ME TROUSLARD, a CORALINE AIRAULT, a JEAN-PHILIPPE HUGNOT, b BAPTISTE CORDIER, c THIERRY DOAN, c ANNE KASTNER ay AND NICOLAS WANAVERBECQ a*y
a Aix-Marseille Univ, PPSN EA 4674, Marseille, France b Universite′ de Montpellier 2, INSERM U1051, Institute for Neuroscience, Ho?pital Saint Eloi. Montpellier, France c Aix-Marseille Univ, IMM UMR 7283 CNRS, Marseille, France
animals. Thus, despite a pursuit of neuronal maturation during the postnatal period, CSF-cNs retain a durable low di?erentiated state. ó 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
Key words: CSF-contacting neurons, PKD2L1, central canal, brainstem, cervical spinal cord, maturity markers.
Abstract—The central canal along the spinal cord (SC.) and medulla is characterized by the presence of a speci?c population of neurons that contacts the cerebrospinal ?uid (CSF). These medullo-spinal CSF-contacting neurons (CSF-cNs) are identi?ed by the selective expression of the polycystin kidney disease 2-like 1 ionic channel (PKD2L1 or polycystin-L). In adult, they have been shown to express doublecortin (DCX) and Nkx6.1, two markers of juvenile neurons along with the neuron-speci?c nuclear protein (NeuN) typically expressed in mature neurons. They were therefore suggested to remain in a rather incomplete maturation state. The aim of this study was to assess whether such juvenile state is stable in postnatal animals or whether CSF-cNs may reach maturity at older stages than neurons in the parenchyma. We show, in the cervical SC. and the brainstem that, in relation to age, CSF-cN density declines and that their cell bodies become more distant from the cc, except in its ventral part. Moreover, in adults (from 1 month) by comparison with neonatal mice, we show that CSF-cNs have evolved to a more mature state, as indicated by the increase in the percentage
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