急性心肌梗死患者血清尿酸水平与心功能变化的相关性研究.docVIP

急性心肌梗死患者血清尿酸水平与心功能变化的相关性研究 　　摘要：目的 探讨急性心肌梗死（AMI）患者血清尿酸（UA）水平与心功能评价指标的相关性。方法 2016年 1 月～2016年 10月入院的 AMI 患者 57 例，根据血清 UA 水平分为高尿酸血症组（n=41）和尿酸正常组（n=116）。比较两组患者一般资料、血液检测指标、超声心动图各指标及 Grace 危险评分，并分析 UA 与各指标的相关性。结果 高尿酸血症组体重指数（BMI）、合并高血压病比例、甘油三酯（TG）、N末端脑钠肽前体（NT-proBNP）、Grace 评分以及左室收缩末期容积（LVESV）较尿酸正常组高（P0.05 或P0.01），而左室射血分数（LVEF）及左室短轴缩短分数（FS）显著降低（P0.05）。单因素相关分析结果显示，高尿酸组尿酸水平与年龄、LDL-C、NT-ProBNP、Grace评分、LVESV和左室舒张末期容积（LVEDV）成正相关（P0.05），与LVEF成负相关（P0.05）。结论 AMI合并高尿酸血症患者左室收缩功能受损更明显，院内死亡风险更高，提示预后更差。 　　关键词：尿酸；急性心肌梗死；心功能 　　The Study of the Relationship between Serum Uric Acid Level and Cardiac Function in Acute Myocardial Infarction Patients 　　ZHOU Wei 　　（Tianjin Hongqiao Hospital，Tianjin 300000，China） 　　Abstract：Objective To investigate the relationship between serum uric acid（UA） concentration and cardiac function in patients with acute myocardial infarction（AMI）. Methods A total of 57 AMI patients in Tianjin hongqiao hospital from January 2016 to October 2016 were enrolled and were divided into high UA group（n=41） and normal UA group（n=116）.Clinical features，blood tests， echocardiogram and GRACE risk scores were compared between the two groups. Results Body mass index （BMI） and hyperuricemia group with hypertension ratio， triglyceride （TG）， N terminal brain natriuretic peptide （NT-proBNP）， Grace score and left ventricular end systolic volume （LVESV） with high normal uric acid group （P 0.05 or P 0.01）， and left ventricular ejection fraction （LVEF） and left ventricular fractional shortening （FS） decreased significantly （P 0.05）. Single factor correlation analysis showed that high uric acid group and uric acid level of age， LDL-C， NT-ProBNP， Grace score， LVESV and left ventricular end diastolic volume （LVEDV） was positively correlated （P 0.05）， and negative correlation with LVEF （P 0.05）.Conclusion Left ventricular systolic function in patients with AMI complicated with hyperuricemia was more obvious， and the risk of in-hospital death was higher， which suggested that the pr