CourtneyA.Sykes-Safety,CanYouParadigm课件.pptVIP

Safety, Can You Paradigm? A Statistical Lament Janet Turk WittesStatistics Collaborative Harms identified late fenflurmine-phentermine (Fen Phen) Rofecoxib (Vioxx) Troglitazone (Rezulin) HRT (Premarin and PremPro) Celecoxib (Celebrex) Telithromycin (Ketek) Rosiglitazone (Avandia) Antidepressants, anti-epileptics…. Could we have identified these harms earlier? Troglitazone (Rezulin) -removed from market in 2000 Lots of liver abnormalities Severe toxicities noted in 1997 Other equally effective drugs didn’t have same problems Could we have identified these harms earl