Fiorentino：Discuss new developments regarding biologics that are FDA-approved for psoriasis.pptVIP

* * * Cases of TB have been reported with all currently marketed TNF inhibitors. As such, screening and appropriate treatment for latent TB prior to initiating anti-TNF therapy is prudent with all agents. While it is inappropriate to compare the rates between products secondary to important differences in total exposure, geographic usage (i.e. patterns of exposure/use in the United States and outside the United States), and patient populations, one should note that cases of disseminated TB have been reported with all agents, underscoring the importance of screening and treatment prior to initiating therapy. The CDC recommends PPD testing be done in all patients prior to treatment with anti-TNF therapy. Via fda AERS postmarketing safety reports * * * * [2007] [OP0215] ANTI-TNF THERAPY AND THE RISK OF SERIOUS POST-OPERATIVE INFECTION: RESULTS FROM THE BSR BIOLOGICS REGISTER (BSRBR)W.G. Dixon, M. Lunt, K.D. Watson, K.L. Hyrich, BSR Control Centre Consortium, D.P.M. Symmons ARC Epidemiology Unit, University of Manchester, Manchester, United KingdomBackground: Surgery is a risk factor for infection in patients with rheumatoid arthritis (RA). It is unclear whether this risk is enhanced by anti-TNF therapy and whether anti-TNF therapy should be stopped prior to elective surgery. UK guidelines suggest that anti-TNF therapy should be stopped 2-4 weeks prior to surgery.Objectives: 1) To examine the risk of serious post-operative infection (SPOI) in patients with RA exposed to anti-TNF therapy at the time of surgery compared to anti-TNF na?ve RA patients; and 2) to compare the rates of SPOI in patients exposed to anti-TNF therapy in the month preceding surgery with the rates of SPOI in patients previously exposed to anti-TNF therapy but not exposed in the month preceding surgery.Methods: All operations prior to 31st July 2006 were identified in patients with RA recruited by the British Society for Rheumatology Biologics Register (BSRBR). Patients who had received ant