线虫抗凝肽的研究进展.pdfVIP

线虫抗凝肽的研究进展 Nematode NovelAntithrombotic AnticoagulantPeptide：A Agent 姜月华1王海萍1，王健伟1，2韩金祥1洪涛1，2 (1山东省病毒学研究所暨山东省医学病毒学重点实验室／卫生部生物技术药物 重点实验室250062；2中国疾病预防控制中心病毒病预防控制所100052) Yuehual Jianweil·2Han Ta01’2 Jiang Wang JirLxian91Hong Instituteof Provincial of Provincial (1Shandong Virology／ShandongKeyLaboratory Medical and of Biotechnological VirologyKeyLaboratory of Health，Jinan250062，ER．China and 2NationalInstituteforViralDiseaseControlPrevention,China CDC，Beijing 100052，PR．China) 摘要 线虫抗凝肽(NAP)是自犬钩口线虫成虫分离得到的一系列具有抗凝作用的 小分子多肽类物质，含有约为75～85个氨基酸，拥有22％的共同序列。NAP抗 凝作用强，药效持久，成本低，临床应用前景好，现已进入III期临床试验评估 阶段。本文就其研究进展做一综述。 Abstract Thenematode a ofantithrombotic anticoagulantpeptides(NAP)arefamily oflowmolecular are。isolatedfromadult non-enzymaticpeptides weights．They with caninumandare ofaround75to85aminoacids a Ancylostoma composed NAPshavedemonstratedand of22％．Since homology potent prominent half-life，excellent relatiVelow anticoagulant bioavailability，andprice， activity,long are tobe inthetreatmentand developed therapeuticagents prevention they promising ofthe hasenteredthePhaseIII ofthromboticdisorders．One