Circulation-2012-D鰎ing-1673-83.pdfVIP

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis Yvonne Do??ring, PhD; Helga D. Manthey, PhD; Maik Drechsler, PhD; Dirk Lievens, PhD; Remco T.A. Megens, PhD; Oliver Soehnlein, MD, PhD; Martin Busch, MSc; Marco Manca, PhD; Rory R. Koenen, PhD; Jaroslav Pelisek, PhD; Mat J. Daemen, MD, PhD; Esther Lutgens, MD, PhD; Martin Zenke, PhD; Christoph J. Binder, MD, PhD; Christian Weber, MD; Alma Zernecke, MD Background??Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are spec