乙型肝炎病毒基因亚型及相关指标临床意义分析.docVIP

乙型肝炎病毒基因亚型及相关指标临床意义分析 　　摘要：目的 探讨乙型肝炎病毒不同基因亚型与病毒复制状况、凝血功能、肝脏功能的关系，以及不同基因亚型的临床意义。方法 选取慢性乙型肝炎、肝硬化、肝癌患者血液标本，检测乙型肝炎病毒基因亚型、病毒载量、凝血功能、肝功能等指标，应用统计软件SPSS 16.0进行分析。结果 本次调查乙型肝炎病毒基因亚型主要为B型和C型，B型略多于C型。但在肝癌患者中，C型所占比例高于B型（P0.05）。结论 本地区乙型肝炎病毒基因亚型主要为B型和C型，C型患者肝脏损害较B型重，提示不同基因亚型可能影响患者体内病毒复制，并引起不同临床损害程度的慢性肝病。 　　关键词：乙型肝炎病毒；基因型 　　Clinical Correlation Research of Hepatitis B Virus Genotypes 　　HUANG Bo， WAN Xiao-tao， ZHANG You-hui，ZHONG Fang-cai 　　（Department of Clinical Laboratory，The First Peoples Hospital of Neijiang， Neijiang 641000，Sichuan，China） 　　Abstract：Objective To understand the distribution of genotypes in Neijiang area， analyze the relationship of different genotypes with virus replication， liver function and coagulation function， investigate the clinical significance of different genotypes. Methods Serum samples were collected from chronic hepatitis B， liver cirrhosis， hepatic cell carcinoma individuals. Hepatitis B virus genotypes， virus replication， liver function and coagulation function were detected. The data was analyzed with SPSS 16.0.Results The main genotypes in Neijiang area were B and C. The C genotype virus replication was significantly higher than that of B genotype（P?0.05）.The proportion of C genotype in hepatic cell carcinoma group exhibited significantly higher than that in B genotype（P?0.05）.No significant difference was found in liver function between B and C genotypes（P0.05）. But significant difference was found in coagulation function between B and C genotypes（P?0.05）. Conclusion The main genotypes in Neijiang area were B and C. The liver damage of patients with C genotype is more serious than that of B genotype， which prompts that hepatitis B virus genotypes may influence on in vivo hepatitis B virus replication and may cause chronic liver disease of different clinical types. 　　Key words：Hepatitis B virus；Genotype 　　病毒性肝炎是严重危害人类健康的疾病，其中乙型病毒肝炎是危害较广泛的慢性传染病，目前全世界大概有近20亿人感染过乙型肝炎病毒，其中有超过3亿人发展为慢性感染者。我国是乙型肝炎病毒感染的高发区，人群中乙型肝炎病毒的感染率高，乙型肝炎表面抗原阳性率高达7.15%。