南开大学医学院.pptVIP

Diuretic Agents Hydrochlorothiazide (氢氯噻嗪) All are absorbed by given orally, Hydrochlorothiazide is absorbed slowly, less than 10 %, t1/2=1.5 hr, excreted unchanged in the urine and not effective when renal function is severely impaired. It is excreted competes with uric acid, so uric acid secretory rate may be reduced. Diuretic Agents Pharmacological effects Diuretic effect moderate, primary site of action is the distal convolute tubule, inhibit the Na+-Cl- co-transporter in the luminal basolateral membrane by a Na+ pump competing for the Cl- binding site which is distinct from the actio