胰岛素治疗22493幻灯片.pptVIP

Therapeutic OptionsInsulins Insulin Preparations Class Agents Human insulins Regular, NPH, lente, ultralente Insulin analogues Aspart, glulisine, lispro, glargine Premixed insulins Human 70/30, 50/50 Humalog mix 75/25 Novolog mix 70/30 Human Insulin A-chain B-chain Zn++ Zn++ Self-aggregation in solution Monomers Dimers Hexamers 21 amino acids 30 amino acids Modified Human Insulin Regular Insulin Short acting Hexamers in Zn2+ buffer Neutral Protamine Hagedorn (NPH) Insulin Intermediate acting Medium-sized crystals in protamine-Zn2+ buffer Lente and Ultralente Insulin Intermediate andLa