大鼠膀胱收缩功能与容量的关系及高血糖对其的影响.pdfVIP

.858. 中华宴串串外科杂志E∞7 年 7 月 1自饲养第 7 期 Chin J üo Sundulv 组泊7.Vol24.No.7 大鼠膀脱收缩功能与容量的关系及高血糖 对其的影响 王新民张木勋赵1TS刘继红 [摘要l 目的 统讨大鼠目牵胧收缩功能与容量的关系及高血糖对其的影响。 方法 6 周初 10 周正常组鼠、6周和 10 周糖尿病观察组鼠、6周和 10 周糖尿病族岛素治疗组以各 14 只，每组各 7 只均以 81410 四通道生理记录仪州IJ进行在体膨胀的容量·压力关系测定及其电剌激下的容量· 压力变化差值关系测定和离体鳞就内壁纵行肌条的妖皮·张力关系测定及其电剌激下的长度·张力 变化差值关系检测等。 结果 正常组、观察组和治疗组均存在基础状态能产生最大筋~压力和电 剌激状态下能产生簸大压力增加值的最适膀E宽容量.也存在电剌激状态下能产生般大张力增加值 的最适肌条长度;且 2 观察组的最大膀脱压力低于 2 正常组 [ (36.1∞主 0.143) vs (39.2∞± 0.139)mmHg、(33.8∞企0.068) vs (39.100 :1: 0.156) mm Hg ，PO.Ol 、PO . OI] 、最大膀脱压力糟 加值和援大张力培加值也明显低于正常组和治疗组(PO.OI) 。结论 正常鼠、糖尿病鼠和糖尿病 踉岛东治疗鼠的膨胀收缩功能均符合气球原理.离血糖可降低其收缩功能. l 关键词 l 糖尿病; 膀M;; 电剌激; 收缩功能 Relatlonsbip betw四n the contractlve Cunction and volume of rat bladder and the effect~ of hyper- glycem1a W ANG Xin-min ,ZHANC Mu-xl响 ， ZHAO Lei , et aL ? Tongji HOJpilaJ, TOI也? Medical Col- lege ,HIJ4ZMng UnWeleilr 01.缸tnce 即ui T.配hTWlcgr ， WI凶an 43∞3O，China [ AbS1J.回 1 Obj创四 To study the contractive rule of rat bladder and the effeCl8 of hy阿Iyce- mia on it. M咄咄 日圳·阳 50 ra阳明陀叩ally grouped ioto 6 (eg. 6 咱ks and 10 weeks normal groups ,6 w民ks and 10 响eks diabetic 伊剧院， 6 WI回k.s and 10 w.出ks diabetic gt咄阴阳atOO with i田u- lin). Seven ra恒。f 回ch group were used to measure 由cir ten5ion~pacity curves of bladder or tension- length of detrusor strip by the physiological apparatus with four channels of type BLAIO. lt部u11s There wcre optimum capacity of blndder and optimum length of detrusor strip in all the normaJ and diabetes and diabetcs treated by insulin groups. The peak valu剧。r the tCflsion-capacity curves oC bladder between 6 weeks dil邮tic and 6 week.s normaJ grωps [( 36. 1∞主O. 143) 四 (39.2∞金0. 1 39) mmHg] ,and 00- Iwcen 10 week.s diabetic and 10 w出ks normal groups [ (33.800 :1: O.础) vs ( 39.100 :1:0 . 156) mm Hg] were dilTcrent ( PO.OI ). And tbe tensi佣占ength of detru胁r strip and their enhan时 ValUI国 after el民- tronic 剖imulus in 6 w四ks or 10 eeks diabetic groups were 10时r than th帽e in6 w.出k.s or 10 w出ks nor- maJ groups and diabelic on饵阳100 by