中空羟基磷灰石复合重组人骨形态发生蛋白2微球体修复骨缺损.docVIP

中空羟基磷灰石复合重组人骨形态发生蛋白2微球体修复骨缺损 唐智明1，熊 龙1，曾建华2，廖新根1，李经堂1，姚爱华3，华福洲4 (1江西省人民医院骨一科，江西省南昌市 330006；2赣县人民医院骨科，江西省赣州市 341100；3同济大学材料学与工程学院，上海市 200092； 4南昌大学第二附属医院麻醉科，江西省南昌市 330006) 引用本文：唐智明，熊龙，曾建华，廖新根，李经堂，姚爱华，华福洲. 中空羟基磷灰石复合重组人骨形态发生蛋白2微球体修复骨缺损[J].中国组织工程研究，2017，21():177-181. DOI:10.3969/j.issn.2095-4344.2017.02.003 ORCID: 0000-0002-7973-196X(唐智明) 文章快速阅读： 文题释义： 中空羟基磷灰石：Lane-Sandhu X射线评分标准：Hollow hydroxyapatite combined with human bone morphogenetic protein-2 microspheres for bone defect repair Tang Zhi-ming1, Xiong Long1, Zeng Jian-hua2, Liao Xin-gen1, Li Jing-tang1, Yao Ai-hua3, Hua Fu-zhou4 (1First Department of Orthopaedics, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China; 2Department of Orthopaedics, People’s Hospital of Ganxian, Ganzhou 341100, Jiangxi Province, China; 3School of Materials Science and Engineering of Tongji University, Shanghai 20092, China; 4Department of Anesthesiology, the Second Affiliated Hospital of Nanchang University, Nanchang 330066, Jiangxi Province, China) Abstract BACKGROUND: Hydroxyapatite (HA) is a good scaffold material, and recombinant human bone morphogenetic protein-2 (rhBMP-2) possesses a strong osteogenic ability, therefore, by which preparing a novel composite material will be helpful for bone repair. OBJECTIVE: To explore the effects of the hollow HA/rhBMP-2 microspheres on the osteogenesis and biomechanics of rabbit bone defects. METHODS: Forty-eight male healthy adult New Zealand white rabbits were randomly divided into three groups (n=16 per group), including composite, single and control groups. Radical defect models were prepared, and the hollow HA/rhBMP-2 and hollow HA scaffolds were implanted into the composite and single groups, respectively. The control group received no treatment. At the 1st day of 4, 8, 12, and 16 weeks after implantation, the level of serum alkaline phosphatase was detected, and the bone healing was assessed through X-ray, three-dimensional