- 1、本文档共5页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Influence of Dendritic Morphology on Axonal Competition
Influence of Dendritic Morphology on Axonal Competition
Arjen van Ooyen
1
, David J. Willshaw
2
and Ger J. A. Ramakers
1
(1) Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
(2) Institute for Adaptive and Neural Computation, Division of Informatics, University of Edinburgh,
2 Buccleuch Place, Edinburgh EH8 9LW, UK
Neurocomputing 32-33 (2000) 255-260
Abstract
The development of nerve connections involves competition among axons for survival promoting
factors, or neurotrophins, which are released by the axons’ target cells. We have extended our model
of axonal competition [11] to study the influence of the target’s dendritic tree on competition. We
show that spatial separation of innervating axons on the target’s dendrites mitigates competition and
permits the coexistence of axons. The model accounts for the finding that in many types of neurons a
positive correlation exists between the size of the dendritic tree and the number of innervating axons
surviving into adulthood [6, 8]. Our results emphasize the importance of postsynaptic dendritic
morphology in the development of specific patterns of nerve connections.
Keywords: competition; neurotrophins; dendrites; morphology
1 Introduction
The development of connections between neurons and their target cells often involves an initial stage of
superinnervation followed by elimination of axons [7]. Competition among innervating axons for target-
derived neurotrophins, which are taken up by the axons via specific receptors at their terminals [1] and
which affect the growth and branching of the axons, is thought to be involved in the elimination of axons
[9].
In many types of neurons, a positive correlation exists between the complexity of the dendritic tree
and the number of innervating axons surviving into adulthood [6, 8]. In the ciliary ganglion of adult
rabbits, for example, neurons that lack dendrites are innervated by a single axon, whereas neurons with
many dendrites are
您可能关注的文档
- HBT neonate.pdf
- HDL 2000机票打印机驱动安装.docx
- hdmi 7511W 芯片资料.pdf
- HDMI Marking Description.pdf
- Hearing Conversation Training Material.ppt
- HearNPVP26蛋白的结构解析.docx
- Heart rate variability in free diving athletes..pdf
- Heat Shock Protein 70 Is Induced in Mouse Human Colon.pdf
- Heat shock-mediated APX gene expression and protection against chilling injury in rice seedlings.pdf
- Heat shock proteins in whiteflies, an insect that accumulates sorbitol in response to heat stress..pdf
文档评论(0)